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- R. Subhashini
- P. Sumathi
- Gayathri Gunalan
- B. Arirudran
- S. Subramanian
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Mahadeva Rao, U. S.
- A Comparative Phytochemical Analysis of Cocoa and Green Tea
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Authors
Affiliations
1 Dept. of Biochemistry, SRM Arts and Science College, Kattankulathur, Kanchipuram, Tamilnadu, IN
1 Dept. of Biochemistry, SRM Arts and Science College, Kattankulathur, Kanchipuram, Tamilnadu, IN
Source
Indian Journal of Science and Technology, Vol 3, No 2 (2010), Pagination: 188-192Abstract
Polyphenols are a large groups of natural compounds widely distributed in variety of plants. They are known to have antioxidant properties with potential health benefits. Green tea and cocoa are the two most widely consumed beverages in the world. Various researches suggest that green tea and cocoa was found to prevent cardiovascular diseases, cancers and kidney stones. The present study is intended to profile the phenols and flavonoids content and to assess the antioxidative capacity in both cocoa and green tea. The results of the study have revealed that one serving of cocoa has higher amount of polyphenols than that of green tea. Hence cocoa froths with antioxidants than green tea and its consumption can improve general health.Keywords
Green Tea, Cocoa, Antioxidants, Free Radicals, Phytochemicals, FlavonoidsFull Text
References
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- Ameliorative Role of Threshold Level of Bilirubin in Newborn Jaundice and Efficacy of Noni Fruit Extract on Phenyl Hydrazine Induced Jaundice Rat
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Authors
Affiliations
1 Department of Bio-Chemistry, S.R.M. Arts and Science College, Kattankulathur-603203, IN
2 Department of Biochemistry, University of Madras, Guindy Campus, Chennai-600 025, IN
1 Department of Bio-Chemistry, S.R.M. Arts and Science College, Kattankulathur-603203, IN
2 Department of Biochemistry, University of Madras, Guindy Campus, Chennai-600 025, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 4 (2011), Pagination: 196-201Abstract
The aims of the present work were to elucidate the role of bilirubin as a free radical scavenger in unconjugated hyperbilirubinemic newborns. Bilirubin above an optimum level is toxic to human systems and is extcreted in urinary and through gastrointestinal tract. It is observed that serum bilirubin up to 85μ mole/l (5mg/dl) has a free radical scavenger activity and exceeding 200μmole/l (12mg/dl) is highly pro-oxidant. Phototherapy is the accepted therapeutic management of jaundiced newborns and has been shown to augment the oxidative stress. The ethanolic extract of Noni fruit administered orally at a dose of 3mg/ml is found to diminish the oxidative stress in erythrocytes of phenylhydrazine–induced unconjugated hyperbilirubinemic jaundiced rats, treated with phototherapy, which ultimately reduces the bilirubin level without inducing additional damages.Keywords
Bilirubin, Free Radical Scavenger, Pro-Oxidant, Phototherapy, Jaundice, Oxidative Stress, Noni.
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- Comparative Biochemical Evaluation on Nutraceutic and Phytotherapeutic Properties of Mengkudu and Midshipman’s Butter – Review
Abstract Views :199 |
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Authors
Affiliations
1 PG Department of Biochemistry, SRM Arts and Science College, Kattankulathur-603203, IN
2 Universiti Sultan Zainal Abidin, Kampus Kota 20300, Kuala Terengganu, MY
1 PG Department of Biochemistry, SRM Arts and Science College, Kattankulathur-603203, IN
2 Universiti Sultan Zainal Abidin, Kampus Kota 20300, Kuala Terengganu, MY
Source
Research Journal of Science and Technology, Vol 3, No 5 (2011), Pagination: 232-237Abstract
Background: Rasayana is a branch of Ayurveda which deals with the ability of the herb to bestow upon the body enhanced capacity of warding off infections and delaying the ageing process. Indigenous natural products have become the alternative way to replace the synthetic medicine.
Aim: This review gives an account of the current knowledge on the Pharmacognosy, phytochemistry and pharmacological aspects of Mengkudu (Morinda citrifolia-Rubiaceae) and Midshipman’s butter (Persea americana- Lauraceae), the ethno medicinal plants.
Nutraceutics: A wide range of phytoconstituents mainly alkaloids, flavonoids, terpenoids, phenolics, vitamins, minerals and many more compounds whose activities have been proved are present in both the fruit extracts.
Pharmacology: The fruits of both plants have been used in traditional medicines to prevent, treat, and cure both communicable and non communicable diseases.
Conclusion: The present review includes detailed epidemiology, phytochemistry, and pharmacological aspects of aqueous extracts of fruits of Mengkudu and Midshipman’s butter in an attempt to provide a direction for further research.
Keywords
Pharmacognosy, Phytochemistry, Pharmacology, Nutraceutics, Epidemiology.- Screening of Biofuel Producing Microalgae from Different Fresh-Water Bodies around Chennai
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Authors
Affiliations
1 SRM Arts and Science College, Kattankulathur, Tamilnadu - 603203, IN
2 University Sultan Zainal Abidin, 20400 Kuala Terengganu, Terengganu, MY
1 SRM Arts and Science College, Kattankulathur, Tamilnadu - 603203, IN
2 University Sultan Zainal Abidin, 20400 Kuala Terengganu, Terengganu, MY
Source
Research Journal of Science and Technology, Vol 3, No 6 (2011), Pagination: 343-345Abstract
Aim: The present study is to carry out in search of high biofuel producing microalgae from local fresh water bodies.
Objective: Biofuel is a clean burning fuel currently being produced from algae, vegetable oils or animal fats. Its chemical structure is that of fatty acid alkyl esters.
Methods: Biofuel is produced by trans-esterification of oils with short chain alcohols or by the esterification of fatty acids. The transesterification reaction consists of transforming triglycerides into fatty acid alkyl ester in the presence of an alcohol such as methanol or ethanol and catalyst such as an alkali or acid with glycerol as a by product. Water samples were aseptically collected from selected water bodies. They were subjected to physicochemical analysis and screening of biofuel producers.
Results: The isolated biofuel producing microalgae were grown on their respective media to obtain biomass and their biofuel producing efficacy. Among 5 species isolated one species showed that high biomass and biofuel yield.
Conclusion: It was concluded that the fresh water bodies found around Chennai are the richest source of native biofuel producers and the chlorella stood first in biofuel producing efficiency in our study.
Keywords
Biofuel, Triglyceride, Fatty Acid Alkyl Esters, Transesterification, Glycerol, Biomass..- Socio, Medico and Economic Impacts on in and around Dwellers of Industrial Effluent Pretentious Areas - A Critical Survey
Abstract Views :198 |
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Authors
Affiliations
1 Department of Economics, Mizan Tepi University, Mizan campus, ET
2 Department of Pharmacology, Universiti Sultan Zainal Abidin, Terengganu, MY
3 Universiti Sultan Zainal Abidin, Kampus Kota, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Terengganu, MY
1 Department of Economics, Mizan Tepi University, Mizan campus, ET
2 Department of Pharmacology, Universiti Sultan Zainal Abidin, Terengganu, MY
3 Universiti Sultan Zainal Abidin, Kampus Kota, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Terengganu, MY
Source
Research Journal of Humanities and Social Sciences, Vol 3, No 2 (2012), Pagination: 182-195Abstract
Background of study: The present study makes a solemn effort to review into the factors affecting the environment and health, and the ways and means to improve the value of life of the people living in and around the industrial area. Objectives: The purposes of the study include the assessment of the quantum of water pollution with reference to the tolerance level given by Environmental Protection Agency and Indian Standard Limits, the approximation of the budgetary recurring expenditure towards treatment for health reparations of the sample families due to water effluence, the identification of the determinants of the inclination to pay and the readiness to accept of the sample families, and the recommendations suitable for policy measures to lessen environmental pollution. Sample Design: A two-tier sample design is the unique feature of the study. The first stage of sampling is the selection of the villages on the basis of distances from the SIPCOT industrial complex. The second stage of the sampling is the selection of families from the sample villages. Method of Analysis: An exploration survey of the area is undertaken with a view to gain insight into the economic conditions and health status of the people in the SIPCOT area. Water samples were collected from all sample villages, and they were analyzed in chemical laboratories. Results and Discussion: Children are affected more than adults by waterborne diseases in all the SIPCOT zones. Adults are mostly affected by respiratory problems, skin diseases, and enteric fever. Conclusion: Information regarding various other methods of control, treatment and disposal of gaseous, liquid and solid wastes from the chemical industries and the pollution effects on health should be collected by the Pollution Control Authorities and educated to the SIPCOT management, and surrounding village people.- Clinical Study of Preventive Potentials of Consumption of Buah naga [Cactaceae] Against Paracetamol–Induced Hepatotoxicity as well as the Other Associated Biological Effects
Abstract Views :189 |
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Authors
Affiliations
1 Universiti Sultan Zainal Abidin, MY
2 Department of Biochemistry, RKM Vivekananda College, Chennai, IN
1 Universiti Sultan Zainal Abidin, MY
2 Department of Biochemistry, RKM Vivekananda College, Chennai, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 1 (2012), Pagination: 16-23Abstract
Objective: Preliminary studies on the effects of dietary supplementation with Buah naga or Red pitaya fruit on some biochemical, and haematological parameters and histological examinations of liver, were investigated in albino rats in which liver damage was induced by paracetamol (PAM). Experimental Design: Thirty six rats were divided into six groups (including hepatotoxic and non - hepatotoxic), and were fed with 5 and 10% Buah naga fruit extract supplemented diet. Methods: Weight changes and parameters including alanine transaminase(ALT), aspartate transaminase(AST), total protein, glucose, total triglyceride(TG), total cholesterol, reduced glutathione(GSH), lipid peroxidation(LPO), packed cell volume(PCV), total and differential leucocyte count were determined using standard methods. Results of Biochemical Parameters: The consumption of Buah naga supplemented diet gain the weight of the animals as well as alteration in the levels of glucose, protein, ALT and AST in the hepatotoxic groups towards normalcy. The GSH level were significantly increased (p<0.05) while TG were reduced in hepatotoxic group fed extract supplemented diet. Glucose was significantly reduced to near normal (p<0.05) in the two treated groups. Similar results observed in cholesterol and LPO status. Results of Haematological Parameters: WBC, Hb, and PCV were significantly reduced in hepatotoxic groups and refurbished in treated animals. The hepatotoxic control had significant reduction in neutrophils count and recuperated to near normal in treated rats. Histological Studies: The necrotic effects of paracetamol seen in the abnormal histological changes were gradually regenerated to its native architecture in the hepatotoxic treated groups. Conclusion: Thus the present study conjectured that Buah naga consumption prevent or treat the PAM induced hepatotoxicity and associated other deleterious effects.Keywords
Buah naga, Paracetamol, Lipid Peroxidation, Necrosis, Hepatotoxicity.- Hepatotoxic Effect of Sodium Valproate Therapy in Epileptic Children
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Authors
Affiliations
1 PG Department of Biochemistry, SRM College of Arts and Science, Chennai-603 203, IN
1 PG Department of Biochemistry, SRM College of Arts and Science, Chennai-603 203, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 3, No 4 (2011), Pagination: 135-138Abstract
Background: Epilepsy is more common in children than in adults. Valproate (VPA) is a widely used drug in the treatment of epilepsy and, compared to other anticonvulsant drugs, is considered safe. However, more serious adverse reactions can occur such as hepatotoxicity and pancreatitis.
Aim: The present study was aimed to evaluate whether children with epilepsy undergoing valproate therapy has been associated with hepatotoxicity. So, a comparative study was done in epileptic children before and after treatment with VPA.
Methods: Serum levels of hepatic marker enzymes, protein and bilirubin profile and prothrombin time in plasma were estimated.
Results: Significant increase (p<0.05) of hepatic marker enzymes was observed in the epileptic children after VPA treatment. There was a significant decrease (p<0.05) in the levels of protein, albumin and globulin in post treated children. The levels of bilirubin showed no significant (p<0.05) changes but the prothrombin time was observed to be increased significantly (p<0.05).
Discussion: The increase in hepatic marker enzymes may reflect enzyme induction and the decrease in protein level showed increase binding of VPA to albumin. Increase in prothrombin time might be synthetic function of liver. The secretory function of liver not affected from the values of bilirubin.
Conclusion: The above results suggest that valproate treatment in epileptic children is associated with mild hepatotoxicity.
Keywords
Sodium Valproate, Hepatic Marker Enzymes, Hepatotoxicity, Epilepsy, Antiepileptic Drug.- Clinical Evaluation to Assess the Efficacy of Ethanolic Extract of Avocado Fruit on Diabetic Dyslipidemia Studied in STZ- Induced Experimental Albino Rats
Abstract Views :182 |
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Authors
Affiliations
1 P.G. Department of Biochemistry, SRM College of Arts and Science, Chennai, IN
2 Department of Biochemistry, KMG College of Arts and Science, Gudiyattam, IN
1 P.G. Department of Biochemistry, SRM College of Arts and Science, Chennai, IN
2 Department of Biochemistry, KMG College of Arts and Science, Gudiyattam, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 7 (2011), Pagination: 1131-1136Abstract
In Diabetes mellitus, the insulin defect reflects in elevated gluconeogenic metabolite accumulation, which leads to excess acetyl Co-A storage, and, in turn, the acetyl Co-A acts as a precursor of lipids directly, and lipoprotein indirectly, synthesis. Thus, hyperlipidemia is an associated complication of diabetes mellitus. Recently, we have reported that ethanolic extract of Persea americana lowered the blood glucose and oxidative stress in diabetic rats. In this present study, the hypolipidemic effect of Persea americana fruit was investigated in streptozotocin-induced diabetic rats. Oral administration of fruit extract (300 mg/kg b.w.) for 30 days resulted in significant reduction in serum and tissue cholesterol, triglycerides, phospholipids and free fatty acids in STZ-diabetic rats. In addition to that, significant decrease in high density lipoprotein while significant increase in low density lipoprotein and very low density lipoprotein, were observed in diabetic rats, which were brought to near normal after 30 days of herbal extract treatment. The results obtained are comparable with glyclazide, a standard drug. Results of the present study indicate that the fruits of Avocado showed antihyperlipidemic effect in addition to its antidiabetic and free radical scavenging activity properties in type 2 diabetic rats.
Keywords
Avocado, Acetyl Co-A, Hyperlipidemia, Lipoproteins, Gluconeogenic, Persea americana.- Secondary Metabolite Screening, Bioactive Compound Extraction, and Disrupting Mitotic Activity of Wild Cabbage [Brassicaceae] towards Cancer Management.
Abstract Views :177 |
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Authors
Affiliations
1 PG Department of Biochemistry, SRM Arts and Science College, Chennai-603203, IN
2 Department of Biochem, Universiti Sultan Zainal Abidin, MY
1 PG Department of Biochemistry, SRM Arts and Science College, Chennai-603203, IN
2 Department of Biochem, Universiti Sultan Zainal Abidin, MY
Source
Asian Journal of Pharmaceutical Research, Vol 2, No 1 (2012), Pagination: 19-31Abstract
Objective: The present study has been formulated with an objective to establish the preliminary phytochemical analysis and antimitotic activity of Brassica oleracea. Method: Brassica oleracea was collected, homogenized and extracted with different solvents. Antimitotic activity of Brassica oleracea was evaluated using the meristamatic cells from the ischolar_main of Allium cepa. Experiments were carried out with incorporation of folic acid in the extract. Results: The preliminary study revealed the presence of flavonoids, steroids, alkaloids, saponins, polyphenols and glycosides. Folic acid inhibited the antimitotic activity of Brassica oleracea extract. The antimitotic activity obtained was compared with methotrexate-a referred anticancer drug. Discussion: The results obtained from the present study pinpoint that antimitotic activity of Brassica oleracea may be due to the presence of flavonoids, steroids, alkaloids, polyphenols and saponins. Conclusion: Hence Brassica oleracea is a promising source of phytochemicals which promote human health by strengthening the human immune system, inactivate cancer-causing substances, protect the heart and eyes from disease, boost enzyme activity to increase the benefits of the various protective enzymes, reduce bad cholesterol levels, and anti-aging.Keywords
Antimitotic, Brassica oleracea, Allium cepa, Polyphenols, Saponins.- Antimicrobial Effect of Separate Extract of Acetone, Ethyl Acetate, Methanol and Aqueous from Leaf of Milkweed (Calotropis gigantea L.)
Abstract Views :184 |
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Authors
Affiliations
1 P.G. Department of Biochemistry, SRM Arts and Science College, Kattankulathur-603203, Kanchipuram District, Tamil Nadu, IN
2 Universiti Sultan Zainal Abidin, Kampus Kota, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Terengganu, MY
1 P.G. Department of Biochemistry, SRM Arts and Science College, Kattankulathur-603203, Kanchipuram District, Tamil Nadu, IN
2 Universiti Sultan Zainal Abidin, Kampus Kota, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Terengganu, MY
Source
Asian Journal of Pharmaceutical Research, Vol 1, No 4 (2011), Pagination: 102-107Abstract
Objective: The present communication attempts to study the antimicrobial activity of leaf of Calotropis gigantea L. Methods: The leaf is subjected to various extraction using acetone, ethyl acetate, methanol and aqueous solvents against different bacterial and fungal organisms using disc diffusion method. Result: The acetone, ethyl acetate, methanol and aqueous extracts were active against all the samples and showed significant antibacterial properties. The methanol, acetone, ethyl acetate and aqueous extracts exhibited less activity against fungal organisms. Conclusion: Thus it may be suggested that leaf extracts of Calotropis gigantea L. may be used to treat oral bacterial diseases.
Keywords
Calotropis gigantea L, Antimicrobial Activity, Disc Diffusion Method.- Accessibility and Availability, Sociodemographic Characteristics, Health Centre Facilities and Knowledge, Attitude and Practice towards Modifiable Lifestyle Diseases among Adult Population in East Coast Malaysia-A Cross-sectional Study
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Authors
U. S. Mahadeva Rao
1,
San San Oo
1,
Nurul Liana Sabrin
1,
Norsyahira Syazwana Mohd Razali
1,
Khairunnisa Khalid
1,
Nurul Farihah Mohamed Nadzari
1,
Thant Zin
1
Affiliations
1 Universiti Sultan Zainal Abidin, MY
1 Universiti Sultan Zainal Abidin, MY
Source
Research Journal of Pharmacy and Technology, Vol 10, No 1 (2017), Pagination: 317-324Abstract
Background: Modifiable Lifestyle Disease (MLD) can give rise to many complications. If left untreated, the disease can affect one's quality of life. MLD can be prevented by modifying our sedentary lifestyle and dietary practice. Introduction: Nowadays, people are aware of the effect of MLDs in their life but the treatment preferences are different among various people. Objective: This study was conducted to identify the treatment seeking behaviour (TSB) among adult populations in East coast Malaysia (Kampung Ladang Sehat, Kuala Terengganu). Method: The survey was conducted by using cross sectional-based questionnaire. The knowledge, attitude and practice among Kampung Ladang Sehat population in East Coast Malaysia with reference to correlation between socio demographic factors and MLD's TSB is studied. Conclusion: The TSB among adult population in Kampung Ladang Sehat is postulated towards down surging according to the correlation between variables used in the study.Keywords
Modifiable Lifestyle Disease, Treatment Seeking Behaviour, Quality of Life, Dietary Practice.- Association between the Usage of Smartphone as the Risk Factor for the Prevalence of Upper Extremity and Neck Symptoms among University Students:A Cross-Sectional Survey Based Study
Abstract Views :164 |
PDF Views:10
Authors
Deivendran Kalirathinam
1,
Manoj Abraham Manoharlal
2,
ChongLi Mei
3,
Chong Kar Ling
3,
Thomas Wong Yong Sheng
3,
Albin Jerome
4,
U. S. Mahadeva Rao
5
Affiliations
1 School of Rehabilitation, Universiti Sultan Zainal Abidin, Kuala Nerus, Kuala Terengganu, MY
2 Saveetha College of Physiotherapy, Saveetha University, Saveetha Nagar, Chennai, Tamil Nadu, IN
3 University Tunku Abdul Rahman, Selangor, MY
4 School of Physiotherapy, AIMST University, Semeling, MY
5 Universiti Sultan Zainal Abidin, Kuala Terengganu, MY
1 School of Rehabilitation, Universiti Sultan Zainal Abidin, Kuala Nerus, Kuala Terengganu, MY
2 Saveetha College of Physiotherapy, Saveetha University, Saveetha Nagar, Chennai, Tamil Nadu, IN
3 University Tunku Abdul Rahman, Selangor, MY
4 School of Physiotherapy, AIMST University, Semeling, MY
5 Universiti Sultan Zainal Abidin, Kuala Terengganu, MY
Source
Research Journal of Pharmacy and Technology, Vol 10, No 4 (2017), Pagination: 1184-1190Abstract
Background: The usage of smartphone played a significant role in everyday life especially among students. Concern has risen universally of possible musculoskeletal symptoms among smartphone users due to excessive use. Objective: To determine the prevalence of neck and upper extremity symptoms among University students who were using a smartphone. Methods: A cross - sectional survey using self - administered questionnaires were conducted on 250 undergraduate students from one of the leading university in Malaysia. Six out of 250 participants (2.4%) were excluded as they were not a smartphone user. The number of participants from two faculties, namely Faculty of Medical and Health Sciences (FMHS) and Faculty of Accountancy and Management (FAM) were determined with stratified random sampling using Kish Leslie sample size formula. Results: The frequency of six measures of smartphone use was ranked from highest to lowest in order: Internet browsing and E - learning (85.20%), making phone calls (78.30%), texting and emails (77.00%), music, video, and pictures (75.40%), gaming (51.20%) and scheduling (32.80%). Out of 244 participants, 49 (20.1%) of the smartphone users were found to have developed some degree of upper extremity and neck symptoms. The prevalence of neck symptoms was the highest with 44 (18.03%) sufferers, followed by right shoulder symptoms (13.93%) and left shoulder symptoms (11.07%). Despite the symptoms experienced, only 5 (10.20%) participants received treatment while 30 participants (61.22%) claimed that they continued using the smartphone during these episodes. Conclusion: It is postulated that there is a positive relationship between smartphone usage and prevalence of upper extremity and neck symptoms. Recommendation: It is high time to disseminate the basic education on proper usage related to ergonomics is warranted to the university students to increase their awareness.Keywords
Prevalence, Upper Extremity, Neck, Symptoms, Smartphone, Students, Six Measures Of Smartphone Use.- Treadmill-Based Locomotor Training with Leg Weights in People with Chronic Stroke
Abstract Views :163 |
PDF Views:3
Authors
Deivendran Kalirathinam
1,
Albin Jerome
2,
Bhagyashri Bhagwan Vichare
3,
Naresh Baskar Raj
1,
U. S. Mahadeva Rao
4
Affiliations
1 School of Rehabilitation, Universiti Sultan Zainal Abidin, Kuala Nerus, Kuala Terengganu, MY
2 School of Physiotherapy, AIMST University, Semeling, MY
3 Breach Candy Hospital, 60 A, Bhulabhai Desai Road, Mumbai, Maharashtra, IN
4 Universiti Sultan Zainal Abidin, Kuala Terengganu, MY
1 School of Rehabilitation, Universiti Sultan Zainal Abidin, Kuala Nerus, Kuala Terengganu, MY
2 School of Physiotherapy, AIMST University, Semeling, MY
3 Breach Candy Hospital, 60 A, Bhulabhai Desai Road, Mumbai, Maharashtra, IN
4 Universiti Sultan Zainal Abidin, Kuala Terengganu, MY
Source
Research Journal of Pharmacy and Technology, Vol 10, No 5 (2017), Pagination: 1485-1490Abstract
BACKGROUND OF STUDY: Novel locomotor training strategies for individuals with disorders of the central nervous system have associated with the improved locomotor function. OBJECTIVES: The goal of this study was to find the effects of treadmill-based locomotor training with leg weights in individuals with chronic stroke. We assessed impairment and gait parameters in functional ambulation persons with chronic stroke. METHODS: We used a Pretest-posttest design. Twenty individuals with chronic stroke who were community ambulatory were recruited. Participants underwent 30-minute treadmill-based locomotor training sessions three times per week for four weeks. The training program involved treadmill walking for 30 minutes with partial body weight support as needed. Leg weights, equivalent to 5% of body weight affixed around the paretic leg. Gait parameters such as cadence, step length, and stride length and the Modified Emory Functional Ambulation Profile (mEFAP) as an outcome measures used. RESULTS: Improvements were more significant in cadence than other gait parameters such as step length and stride length. The more significant improvement was seen in step length than in stride length. In mEFAP, 5.98% improvement was seen showing enhanced the functional ambulatory capacity of participants. In Chedokemcmaster Stroke Assessment Activity Inventory, 4.27% improvement was seen. CONCLUSION: This study demonstrates that treadmill-based locomotor training combined with leg weights could be a feasible approach for improving the ability to perform complex walking tasks, such as stair climbing, in individuals with chronic stroke.Keywords
Stroke, Weight Load, Treadmill, Modified Emory Functional Ambulation Profile.- Screening of Phytochemicals and Antibacterial Activity of Marine Red Alga Portieria hornemannii (Lyngbye) P. C. Silva
Abstract Views :187 |
PDF Views:0
Authors
Affiliations
1 Division of Algal Biotechnology and Bionano Technology, Post Graduate and Research Department of Botany, Pachaiyappa’s College, Chennai – 600 030, IN
2 School of Basic Medical Sciences, Faculty of Medicine, University Sultan Zainal Abidin, Jalan Sultan Mahmud, 20400, Kuala Terengganu, Terengganu, MY
3 Department of Chemistry, Pachaiyappa’s College, Chennai – 600 030, IN
1 Division of Algal Biotechnology and Bionano Technology, Post Graduate and Research Department of Botany, Pachaiyappa’s College, Chennai – 600 030, IN
2 School of Basic Medical Sciences, Faculty of Medicine, University Sultan Zainal Abidin, Jalan Sultan Mahmud, 20400, Kuala Terengganu, Terengganu, MY
3 Department of Chemistry, Pachaiyappa’s College, Chennai – 600 030, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 9, No 3 (2017), Pagination: 131-136Abstract
The evaluation of phytochemicals and antimicrobial activities of marine red alga Portieria hornemannii against bacterial pathogens have been established in the present investigation. The quantitative phytochemical screening of the methanol extract of P. hornemannii, showed a maximum number of natural products such as tannins, flavonoids, glycosides, phenols, saponins, terpenoids, etc. The antimicrobial activity of methanol extract of P. hornemannii showed the highest inhibition against Staphylococcus aureus (77.77%) and the chloroform extract showed the lowest activity against Pseudomonas aeruginosa by showing (52.63%) as evaluated by disc diffusion method. Our findings provide the evidence that the methanol extract of P. hornemannii possesses the good antimicrobial activity and hence, the alga proves to be an effective therapeutic agent.Keywords
Phytochemical, Portieria hornemannii, Antibacterial Activity, Therapeutic Agent.References
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- Comparative study of Probiotic Bacteria on ornamental fish giant gourami, Osphronemus goramy for its survival and growth
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Authors
Affiliations
1 PG & Research Department of Microbiology, Hindustan College of Arts & Science, Padur, Chennai – 603 103, IN
2 PG & Research Department of Biotechnology, Hindustan College of Arts & Science, Padur, Chennai – 603 103, IN
3 Universiti Sultan ZainalAbidin, Terengganu, MY
1 PG & Research Department of Microbiology, Hindustan College of Arts & Science, Padur, Chennai – 603 103, IN
2 PG & Research Department of Biotechnology, Hindustan College of Arts & Science, Padur, Chennai – 603 103, IN
3 Universiti Sultan ZainalAbidin, Terengganu, MY
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 262-268Abstract
Production of high quality giant gourami is considered essential to prevent the disease outbreak, survival and growth at aquarium. This paper deals with the production of high quality giant gourami, Osphronemus goramy using probiotics. Materials and Methods: This experiment was designed in such way that stocking the Giant gourami in fourgroups, the first one as control without probiotics and the second as experimental with Bacillus sp, third with Lactobacillus spand the fourth as consortium; a mixture of Bacillus sp and Lactobacillus sp. Results and Discussion: The results were compared in terms of quality of Giant gourami. The fish treated with consortium exhibited highest growth rate (Body Weight-4.13+8.24 gm) and survival of 95% at Total Length– 4.23+8.47 cm stage. The upper most growth rate was noted in group IV treated daily with consortium. This treatment group improved in mean weight from 4.13 to 8.27 with an average growth rate of 0.069% per day. This was significantly better than the control group I which grew from 4.15 to 5.83 g with an average of 0.028 % per day. In the experimental tanks the water treated with probiotics played a key role in maintaining the water quality parameters and keeping the ammonia level less than 1.0 ppm. Conclusion: It was established that the use of probiotics plays a very important role in maintaining the water quality, survival and growth rate in ornamental fish forming systems.Keywords
Bacillus sp, consortium, Giant gourami, Lactobacillus sp, Osphronemus goramy, Probiotics.References
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- Phenyl Propanoid Glycoside, An Eleutheroside derivative in the Regulation Carbohydrate Metabolism in Hepatic Tissues in T2DM experimental Rats
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1 School of Basic Medical Sciences, Universiti Sultan Zainal Abidin, 20400 Kuala Terengganu, MY
1 School of Basic Medical Sciences, Universiti Sultan Zainal Abidin, 20400 Kuala Terengganu, MY
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Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 283-290Abstract
The enzymes that control glucose metabolism in the liver tissue are considered as potential targets forthe maintenance of normal glycemic control in diabetic individuals. Search for new drugs with more efficacies and without side effects preferably from plant origin continues. Phenyl propanoid glycoside, an eleutheroside derivative is one such phyto secondary metabolite which lacks scientific validation for its folklore use. In the present study it was aimed to systematically study the efficacyof phenyl propanoid glycoside (syringin) (5mg/kg.b.w./rat for 30 days) in the regulation of glucose homeostasis modulating theactivities of carbohydrate metabolizing enzymes in hepatic tissues of T2DM in rats. The assay of activities of carbohydrate metabolizing key enzymes of glycolysis, and pentose phosphate and gluconeogenic pathways in hepatic tissues were performed. The altered activities of key enzymes of these pathways in hepatic tissues of diabetic rats were significantlyreverted to near normalcy upon oral treatment with syringin. In addition, oral administration of syringin to experimental diabetic groups of rats showed significant reduction in the levels of fasting bloodglucose and glycosylated hemoglobin and increased level of plasma insulin and hemoglobin. Thus, thepresent data validated that the oral administration of syringin to diabetic rats regulates glucosehomeostasis by regulating the activities of carbohydrate metabolizing enzymes.Keywords
Diabetes, Hemoglobin, Insulin, Streptozotocin, Syringin.References
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- Isolation and Characterization of Phytochemical Constituents and its Antibacterial Activity of Brassica oleracea var acephala
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1 Universiti Sultan Zainal Abidin, 20400 Terengganu, MY
2 PG & Research Department of Microbiology, Hindustan College of Arts & Science, Padur, Chennai–603103, IN
3 PG & Research Department of Biotechnology, Hindustan College of Arts & Science, Padur, Chennai–603103, IN
1 Universiti Sultan Zainal Abidin, 20400 Terengganu, MY
2 PG & Research Department of Microbiology, Hindustan College of Arts & Science, Padur, Chennai–603103, IN
3 PG & Research Department of Biotechnology, Hindustan College of Arts & Science, Padur, Chennai–603103, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 297-302Abstract
Objectives: Traditional medicines are mostly depends on medicinal plants. These are considered as good resources of ingredients which can be used in drug formulation and combination. Hence the present study is to investigate the valuable pharmacological activities ofBrassica oleracea var acephala. Materials and Methods: The collected fresh foliage were washed, dried, chopped and powdered for the preparation of ethanolic crude extract. By using this ethanolic crude extract of Brassica oleracea var acephala phytochemical analysis were done. The crude extract was tested against various bacterial strains and fungal strains by Agar Well diffusion assay. Then the crude extract was subjected to GC-MS and FTIR analysis for the identification of bioactive compounds. Results: Preliminary phytochemical test showed the presence of Phenolic compounds, Tannins, Terpenoids, Phytosterol and Flavonoids.The results of the antibacterial screening of the crude extract on the S.aureus showed more inhibition. The ethanolic crude extract showed that eleven compounds were identified through GC-MS and FTIR analysis. Conclusion: Brassica oleracea var acephala has been studied and the results of the present investigation revealed that the leaf extract contained high phytochemical activity. The present study attempted to establish a relationship between ethnopharmacological claims and bioactive constituents present in Brassica oleracea var Acephala against all possible targets for cancer.Keywords
Brassica oleracea var acephala, Phytochemical Screening, Antibacterialactivities, GC-MS Analysis, FTIR Analysis.References
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- Relative Bioremediation of Used engine oil Contaminated soil from an Industrialised area by Various microbes
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Authors
Affiliations
1 PG & Research Department of Biotechnology, Hindustan College of Arts & Science, Padur, Chennai–603 103, IN
2 PG & Research Department of Microbiology, Hindustan College of Arts & Science, Padur, Chennai–603 103, IN
3 Universiti Sultan Zainal Abidin, 20400 Terengganu, MY
1 PG & Research Department of Biotechnology, Hindustan College of Arts & Science, Padur, Chennai–603 103, IN
2 PG & Research Department of Microbiology, Hindustan College of Arts & Science, Padur, Chennai–603 103, IN
3 Universiti Sultan Zainal Abidin, 20400 Terengganu, MY
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 331-338Abstract
Aim:The present study is to degrade the engine oil through microbes from the industrialized areas in and around Chrompet, Chennai. Engine oil contaminated soil samples were collected from different locations of Chrompet which is located 35 KM away from Chennai. Methods:As a result of spread plate technique the microbial colonies were enumerated and three different organisms such as bacteria namely Pseudomonas sp and Bacillus sp.Actinomycetesnamely Streptomyces spand funginamely Aspergillus flavus and Aspergillus nigerwereidentified. The bacterial colonies were identified by morphological and biochemical techniques using the taxonomic scheme. pH and optical density (growth rate) was determined for Pseudomonas sp, Bacillus sp, consortium (Pseudomonas sp and Bacillus sp), Streptomyces sp,Aspergillusflavus and Aspergillus nigerto the concentration from 1ml to 5ml for 16 days. Results:All the isolated microorganisms had the potential to degrade the engine oil. Comparatively the bacterial consortium had the highest potential to degrade the engine oil.Summary:This formulation may be the best solution to solve the land pollution by engine oil and also to conserve the natural environment.Keywords
Aspergillus flavus, Aspergillus niger, Bacillus sp, Consortium, Engine oil, Pseudomonas sp, Streptomyces sp.References
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- Unraveling the Association of Tobacco Smoking (Nicotine) with Gut and Adipocyte Appetite Regulator Hormones–A Systematic Review
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1 Universiti Sultan Zainal Abidin, 20400 Terengganu, MY
1 Universiti Sultan Zainal Abidin, 20400 Terengganu, MY
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Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 913-919Abstract
Lifestyle behaviour is the cause of about 70%–80% deaths in developing countries. Risk factors, such as smoking, alcohol consumption, physical inactivity, obesity, and poor nutrition are the major causes of mortality that are crucial for researchers and policymakers to improve health and reduce preventable deaths in the developing countries. In specific, cigarette smoking has an inverse implication with body weight or body mass index (BMI). Smoking cessation has been linked to weight gain indirectly mediated through gut and adipocyte appetite regulating hormones. This systematic review is achieved through MEDLINE search to collect the data which support this idea using PubMed, Google and MEDLINE databases.Keywords
Association, Tobacco Smoking, Nicotine.References
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- In Silico Analysis of the Betuline from the Fiddler Crab, Uca annulipes and its Antimicrobial as Well as Anti Lung Cancer Activities.
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1 Universiti Sultan ZainalAbidin, Terengganu, MY
2 Department of Biotechnology, Hindustan College of Arts & Science, Padur, Chennai – 603 103, IN
3 Department of Microbiology, Hindustan College of Arts & Science, Padur, Chennai – 603 103, IN
1 Universiti Sultan ZainalAbidin, Terengganu, MY
2 Department of Biotechnology, Hindustan College of Arts & Science, Padur, Chennai – 603 103, IN
3 Department of Microbiology, Hindustan College of Arts & Science, Padur, Chennai – 603 103, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1849-1856Abstract
Introduction: <i>In silico</i> analysis of the bioactive compound betuline from the fiddler crab, Uca annulipes and its antimicrobial activities were studied. The fiddler crabs, Uca annulipes were collected from Muttukadu Estuary located on the Kanchipuram District, Tamil Nadu, India, 35 K.M away from Chennai, on the East Coast Road route to Kovalam. Materials and Methods: Fiddler crabs were collected by hand picking method. From the muscle mass of the Crab the bioactive compound was isolated by GC-MS analysis. Molecular docking was performed to identify the protein ligand responsible for the affinity with lung cancer causing tumour cells. Results and Discussion: Hence betuline is the potential lead molecule for the inhibition of lung cancer protein and the most important residues for potential drug target as carbon hydrogen bond, conventional hydrogen bond and Vander Waals interaction. In vitro studies of antimicrobial activities clearly indicated that the different concentrations of betuline bioactive compound have the potential to control the bacteria such as Escherichia coli and Pseudomonas aeruginosa. In vitro studies of anticancer activities also evidently showed the different concentrations of bioactive compound betuline have the potential to control the proliferation of lung cancer cells. Conclusion: Reports are very scanty on this species studied and the reports are very old and hence this present investigation would give latest information on the isolation of bioactive compound for the production of pharmaceutical drugs against the lung cancer. These results will be decisive factor for determining a lead bioactive compound for further drug discovery process for the lung cancer.Keywords
Betuline, Escherichia coli, Lung Cancer, Pseudomonas aeruginosa and Uca annulipes.References
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- In Silico Analysis of the Phenylephrine from the Sand Crab (Emerita asiatica) for its Antimicrobial Activities
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1 Universiti Sultan Zainal Abidin, Terengganu, MY
2 Research Department of Biotechnology, Hindustan College of Arts and Science, Padur, Chennai – 603103, IN
3 Research Department of Microbiology, Hindustan College of Arts and Science, Padur, Chennai – 603103, IN
1 Universiti Sultan Zainal Abidin, Terengganu, MY
2 Research Department of Biotechnology, Hindustan College of Arts and Science, Padur, Chennai – 603103, IN
3 Research Department of Microbiology, Hindustan College of Arts and Science, Padur, Chennai – 603103, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2145-2152Abstract
Aim: The present investigation gives a detailed report on the analysis of the bioactive compound isolated from the sand crab Emerita asiatica is having better relation with vasoconstriction. Methods: The sand crab Emerita asiatica were collected from Thiruvidandhai beach located on the Kanchipuram District, Tamil Nadu, India, 41 K.M away from Chennai, on the East Coast Road route to Mahabalipuram. Sand crabs were collected by hand picking method. From the muscle mass of the Crab the organic compound was isolated by GC-MS analysis. Molecular docking was also performed to identify the protein ligand responsible for the constriction of blood vessels. Results: The isolated bioactive compound was identified as phenylephrine, an α1 adrenergic receptor which has the potential to lead the molecule for the vasoconstriction. In vitro studies of antibacterial activities clearly indicated that the different concentrations of phenylephrine have the antibacterial activity against the bacteria such as Klebsiella pneumoniae and Staphylococcus aureus. Summary: The present investigation would give latest information on the isolation of bioactive compound for the production of pharmaceutical drugs from marine organisms. These results will be decisive factor for determining a lead bioactive compound for further drug discovery process for the vasoconstriction.Keywords
Emerita asiatica, Klebsiella pneumoniae, Phenylephrine, Staphylococcus aureus, Vasoconstriction.References
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